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Poor Sleep Quality and QOL in Patients with COPD

Sleep; ePub 2018 Mar 9; Zeidler, Martin, et al

Poor sleep quality represents a potentially modifiable risk factor for poor quality of life in patients with chronic obstructive pulmonary disease (COPD), over and above demographics and smoking history, disease severity, and risk for obstructive sleep apnea (OSA), a recent study found. Baseline data from 1,341 participants [892 mild/moderate COPD (FEV1 ≥ 50% predicted); 449 severe COPD (FEV1 < 50%)] were used to perform nested (blocks) regression models to predict quality of life (Short Form-12 mental and physical components and St. George’s Respiratory Questionnaire). Dependent measures used for the nested regressions included the following: Block 1: demographics and smoking history; Block 2: disease severity; Block 3: risk for OSA (Berlin questionnaire); and Block 4: sleep quality (Pittsburgh Sleep Quality Index [PSQI]). Researchers found:

  • Over half of participants with COPD reported poor sleep quality (Mean PSQI 6.4 ± 3.9; 50% with high risk score on the Berlin questionnaire).
  • In all nested regression models, sleep quality (Block 4) was a significant predictor of poor quality of life, over and above variables included in blocks 1–3.


Zeidler MR, Martin JL, Kleerup EC, et al, SPIROMICS Research Group. Sleep disruption as a predictor of quality of life among patients in the subpopulations and intermediate outcome measures in COPD study (SPIROMICS). [Published online ahead of print March 9, 2018]. Sleep. doi:10.1093/sleep/zsy044.