Trials Clarify Benefit of PFO Closure After Stroke

Closure of a patent foramen ovale after cryptogenic stroke reduces recurrent stroke risk, according to results from three randomized trials.

Neurology Reviews. 2017 November;25(11):14-15

October 27, 2017|Neurology

Farb A, Ibrahim NG, Zuckerman BD. Patent foramen ovale after cryptogenic stroke - assessing the evidence for closure. N Engl J Med. 2017;377(11):1006-1009.

Mas JL, Derumeaux G, Guillon B, et al; CLOSE Investigators. Patent foramen ovale closure or anticoagulation vs. antiplatelets after stroke. N Engl J Med. 2017;377(11):1011-1021.

Ropper AH. Tipping point for patent foramen ovale closure. N Engl J Med. 2017;377(11):1093-1095.

Saver JL, Carroll JD, Thaler DE, et al; RESPECT Investigators. Long-term outcomes of patent foramen ovale closure or medical therapy after stroke. N Engl J Med. 2017;377(11):1022-1032.

Søndergaard L, Kasner SE, Rhodes JF, et al; Gore REDUCE Clinical Study Investigators. Patent foramen ovale closure or antiplatelet therapy for cryptogenic stroke. N Engl J Med. 2017;377(11):1033-1042.