If you work on the front lines of medical care treating patients with hepatitis, you may not have time to review all the hepatitis research that enters the medical literature every month. Here’s a quick look at some notable news items and journal articles published over the past month, covering a variety of the major hepatitis viruses.
A recent study suggested that hepatitis B virus (HBV)-DNA testing should be considered routinely, and also in other clinical implications associated with occult hepatitis B virus infection.
German researchers said that stopping or interrupting treatmentwith HBeAg-negative chronic hepatitis B should be further investigated as a strategy to accelerate HBsAg loss.
Despite its high variability, the hepatitis C virus (HCV) is under strict evolutionary constraints, most probably toduring the replication cycle, according to a study in Virus Evolution.
The high burden of chronic hepatitis B virus infection in Asian countries is ato prevent chronic HBV complications within health care systems, according to a meta-analysis in the International Journal of Infectious Diseases.
Recent research suggests that a transition to newer direct acting antivirals ismore generally to improve treatment outcomes for hepatitis C virus–infected patients.
Ribavirin is an effective treatment for hepatitis E virus (HEV) infection, according to a recent review study,to determine which other antiviral agents are of clinical utility in treating HEV in the minority of patients who do not respond to ribavirin.
Robust HEV-specific T-cell responses generated during acute disease, according to a study in Hepatology, but decline in magnitude and polyfunctionality over time. The authors said that defining HEV T-cell targets will be important for the investigation of HEV-associated autoimmune disease.
A recent study indicated that theof hepatitis C virus infection – between HIV-positive men who have sex with men and people who inject drugs – has an impact on HIV coinfection and HCV reinfection.
A French study found that the rate of patients failing to return for the results of HIV, HBV, HCV, and syphilis testing is a problem, but, such as phone texting, might be a partial solution in conjunction with rapid tests for diagnosis.
In chronic hepatitis C virus infection, theis mediated by the complement system, mainly through complement receptor 2 (CD21), in conjunction with the CD19 and CD81 complex, according to a study in Hepatology.
An Italian study found that virological response at week 8 of pegylated interferon and ribavirin therapy in hepatitis C–infected childrenof sustained virologic response.
A recent study found that interferon treatment increased, rather than decreased, hepatitis C virus long double-stranded RNA (dsRNA) in patients. The authors said this unexpected finding suggests that, potentially to antagonize antiviral defenses.
A vaccine study in Argentina found that single-dose universal hepatitis A immunization in 1-year-old childrenfor up to 9 years.
A Japanese study found that CD14+ monocyte-derived galectin-9in chronic hepatitis C virus infection, which might be associated with liver injury and persistent infection.
Sofosbuvir and ribavirin for 6 weeks was not effective, according to results from the DARE-C II study.
A study in Hepatology found that a single broadly neutralizing antibody can prevent acute hepatitis C virus infection without, and may complement direct-acting antivirals to reduce the emergence of RAVs.
Vaccination with DTPa-HBV-IPV/Hib (diphtheria-tetanus-acellular pertussis–hepatitis B–inactivated poliovirus/Haemophilus influenza type b) in infancy inducesagainst hepatitis B virus, a recent study found, as revealed by the strong anamnestic response to the hepatitis B vaccine challenge in 12- to 13-year-old adolescents.
Chronic hepatitis C virus infection appears to disrupt theeven after viral clearance, investigators found, indicating HCV cure does not lead to complete immunological restitution.
Among the largest U.S. community-based real-world cohort of Asian chronic hepatitis C virus genotype 6 patients treated with all-oral sofosbuvir/ledipasvir without ribavirin, sustained viral response at 12 weeks was, validating current HCV genotype 6 treatment guideline recommendations.
Lower serum albumin and higher ASTin HIV/HCV-coinfection, but much less so in HIV-monoinfected individuals, reported a study in the journal AIDS.
A retrospective study of 11 European pediatric HIV cohortswith hepatitis C virus and suffering from progressive liver disease, which investigators said underscores the need for close monitoring and for earlier and more effective HCV treatment.
Chinese investigators have developed and validated a novel classification and regression tree (CART) analysis model that they say isfor predicting 3-month mortality of patients with acute-on-chronic hepatitis B liver failure.
A study in Lancet Infectious Diseases confirmed thatto the global burden of disease for HIV, hepatitis C, and hepatitis B.