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Acute Myocardial Infarction After Influenza

N Engl J Med; 2018 Jan 25; Kwong, Schwartz, et al

There was a significant association between respiratory infections, especially influenza, and acute myocardial infarction (AMI), according to a recent study that evaluated the association between laboratory-confirmed influenza infection and hospitalization for AMI. The risk interval was defined as the first 7 days after respiratory specimen collection and the control interval as 1 year before and 1 year after the risk interval. Researchers found:

  • 364 hospitalizations for AMI that occurred within 1 year before and 1 year after a positive test for influenza were identified.
  • 20 hospitalizations (20 admissions per week) occurred during the risk interval and 344 (3.3 admissions per week) occurred during the control interval.
  • The incidence ratio of an admission for AMI during the risk interval vs the control interval was 6.05.
  • Incidence ratios for AMI within 7 days after detection of influenza B, influenza A, respiratory syncytial virus, and other viruses were 10.11, 5.17, 3.51, and 2.77, respectively.

Citation:

Kwong JC, Schwartz KL, Campitelli MA, et al. Acute myocardial infarction after laboratory-confirmed influenza infection. N Engl J Med. 2018;378:345-353. doi:10.1056/NEJMoa1702090.

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Influenza Vaccine Effectiveness & Early Exposures , J Infect Dis; ePub 2018 Jan 18; Flannery, et al

FDA Expands Indication for Influenza Vaccine, GSK news release; 2018 Jan 11

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