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Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Acute Myocardial Infarction After Influenza

N Engl J Med; 2018 Jan 25; Kwong, Schwartz, et al

There was a significant association between respiratory infections, especially influenza, and acute myocardial infarction (AMI), according to a recent study that evaluated the association between laboratory-confirmed influenza infection and hospitalization for AMI. The risk interval was defined as the first 7 days after respiratory specimen collection and the control interval as 1 year before and 1 year after the risk interval. Researchers found:

  • 364 hospitalizations for AMI that occurred within 1 year before and 1 year after a positive test for influenza were identified.
  • 20 hospitalizations (20 admissions per week) occurred during the risk interval and 344 (3.3 admissions per week) occurred during the control interval.
  • The incidence ratio of an admission for AMI during the risk interval vs the control interval was 6.05.
  • Incidence ratios for AMI within 7 days after detection of influenza B, influenza A, respiratory syncytial virus, and other viruses were 10.11, 5.17, 3.51, and 2.77, respectively.


Kwong JC, Schwartz KL, Campitelli MA, et al. Acute myocardial infarction after laboratory-confirmed influenza infection. N Engl J Med. 2018;378:345-353. doi:10.1056/NEJMoa1702090.

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