Dose-escalated radiation therapy brings mixed results in prostate cancer

Patients in the high-dose arm less often went on to salvage therapy; however, investigators noted that they also had more toxic effects. compared with patients in the standard radiotherapy arm.

“The advantage of avoiding or delaying the adverse effects of these therapies has to be weighed against the increased rate of RT-related morbidity with dose escalation,” Dr. Michalski and his associates wrote.

Dr. Michalski reported no conflicts of interest. The co-authors reported several conflicts of interest, including ties to ViewRay, Augmenix, Sanofi, AstraZeneca, AbbVie, and other companies.

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SOURCE: Michalsky Jeff M et al. JAMA Oncol. 2018 Mar 15. doi: 10.1001/jamaoncol.2018.0039.