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Zilucoplan improved efficacy outcomes in myasthenia gravis
The complement C5 inhibitor had a similar magnitude of clinical effect as that seen in eculizumab studies.
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Critical care admissions up for pediatric opioid poisonings
ORLANDO – Attempted suicide has represented an increasingly large proportion of these severe poisonings.
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Adding pembrolizumab to chemo doubled pCR rates in early-stage breast cancer
The doubling of pathologic complete response rates was seen in all three biomarker signatures studied.
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Glioma trials should track living well, not just longer
“Patients want to live longer, but they also want to continue to function as well as possible for as long as possible,“ said Terri S. Armstrong,...
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Value of very early etanercept plus methotrexate not confirmed in real-world RA trial
In the open-label VEDERA trial, differences in remission rates were not in line with an outsized effect suggested by exploratory analysis of an...
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Walk test may predict complications after lung cancer surgery
Findings suggest role for curative resection in patients with moderately decreased lung function but a longer 6-minute walk distance,...
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Dietary flavonol intake linked to reduced risk of Alzheimer’s
A class of polyphenols found in fruits and vegetables was associated with lower rates of Alzheimer’s in an observational study, setting the stage...
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Genetic factor linked to impaired memory after heading many soccer balls
Findings, while preliminary, may be evidence of “early subclinical effects” in those with high levels of ball-heading exposure.
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T-VEC plus pembrolizumab yields promising response rate in phase 2 sarcoma study
About one in three patients had a response, translating into the highest objective response rate seen in a study of unselected sarcoma patients...
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Start of myeloma therapy may be delayed for women, minorities
Timeliness of treatment should be addressed urgently because of potential effects on disease morbidity, quality of life, and survival.
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‘Simple’ model predicts severe neutropenia risk in lung cancer patients
New tool performs favorably compared with existing, non–lung-cancer-specific model, though prospective validation is needed.
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Decreased incidence, survival in low-grade serous ovarian cancer illustrate ‘diagnostic shift’
Relative to serous borderline ovarian tumors, low-grade serous ovarian cancer cases declined precipitously through 2000, with a trend toward...
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Sharp declines for lung cancer, melanoma deaths fuel record drop in cancer mortality
Reductions in smoking are largely responsible for the lung cancer progress, while immunotherapy and targeted treatments have improved survival in...