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Milrinone beats dobutamine in extending survival in HF
PHILADELPHIA – Survival benefit favored milrinone regardless of indication for use in continuous outpatient intravenous inotropic therapy.
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Clinical trial enrollment linked to lower death rate in lung cancer patients
ALEXANDRIA, VA. – Access to promising agents, enhanced supportive care, or both could provide direct patient benefit.
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Out-of-pocket cost of oral TKIs linked to poor lung cancer survival
ALEXANDRIA, VA. – If confirmed in a nationally representative study, findings could have implications for health policy and oncology practice.
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Pyrotinib bests lapatinib in HER2+ metastatic breast cancer treatment
The pan-ErbB inhibitor pyrotinib plus capecitabine had manageable toxicity, a significantly higher ORR, and significantly longer PFS, compared...
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HIV drug may enhance efficacy of chemoradiation in locally advanced lung cancer
Strategy incorporating protease inhibitor nelfinavir yields promising efficacy, acceptable toxicity in locally advanced non–small cell lung cancer...
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PCSK9 inhibition cuts events in very-high-risk groups
ODYSSEY OUTCOMES analyses peg prior CABG and polyvascular disease as targets for alirocumab.
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Pretreatment CT data may help predict immunotherapy benefit in ovarian cancer
Fewer sites of disease and lower intratumor heterogeneity on contrast-enhanced CT may indicate a higher likelihood of durable response to immune...
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Recurrence score may help predict chemotherapy benefit in grade 3 breast cancers
In data that complement the TAILORx findings, chemotherapy was not linked with significantly improved OS for those with a low recurrence score...
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USPSTF expands BRCA1/2 testing recommendations
Personal cancer history, ancestry now key factors in decision to assess, counsel, and test for potentially harmful mutations in BRCA1/2 genes.
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Post-TAVR anticoagulation alone fails to cut stroke risk in AFib
By contrast, antiplatelet therapy linked to reduced risk of stroke, whether or not oral anticoagulation was used in this PARTNER II substudy.
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Dabrafenib plus trametinib yields long-term benefit in melanoma patients
A long-term survival benefit was seen in about a third of patients with metastatic or unresectable melanoma who underwent first-line treatment...
Article
Novel translocation inhibitor shows efficacy in treatment-naive HIV-1–infected adults
Potent, first-in-class antiretroviral drug may eventually allow for once-weekly or once-monthly dosing, investigator says.
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Antiretroviral-eluting implant could provide HIV prophylaxis for a year or more
The long-term islatravir implant could one day provide an easier adherence alternative for many.
Article
Two-drug integrase inhibitor–based regimen noninferior to standard in HIV-infected adults
In light of these findings and those from other studies, it may be time to “rethink the position of dual therapy in the international guidelines...
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POEM outperforms pneumatic dilation in randomized achalasia trial
Higher success rate, but also a higher rate of reflux esophagitis, seen in patients with previously untreated achalasia.