Emerging data help inform immunotherapy for urothelial cancer
REPORTING FROM GUCS 2018
Median overall survival was 10.3 months and 7.3 months, respectively. Corresponding 1-year survival rates were 44.4% and 29.8%, and corresponding 2-year survival rates, 27.0% and 14.3%.
At 24 months, 60.6% of patients in the chemotherapy arm had received an immunotherapy agent, including some who had received pembrolizumab as part of crossover, Dr. Bellmunt noted.
Overall survival benefit was generally similar across subgroups, including patients with PD-L1–positive tumors (defined as a combined positive score of 10% or higher) (HR, 0.56; P = .00153) and patients with PD-L1–negative tumors (HR, 0.75; P = .00859).
The lack of a progression-free survival benefit of pembrolizumab over chemotherapy in the initial analysis (HR, 0.98; P = .420) persisted in the updated analysis (HR, 0.96; P = .317).
