Clinical Inquiries
Clinical Inquiries
What treatments relieve arthritis and fatigue associated with systemic lupus erythematosus?
EVIDENCE-BASED ANSWER: Hydroxychloroquine and chloroquine improve the arthritis associated with mild systemic lupus erythematosus (SLE)—producing...
Clinical Inquiries
Do oral contraceptives put women with a family history of breast cancer at increased risk?
EVIDENCE-BASED ANSWER: No. Modern combined oral contraceptive pills (OCPs) don’t increase breast cancer risk in women with a family history (...
Clinical Inquiries
What is the best nonsurgical therapy for pelvic organ prolapse?
EVIDENCE-BASED ANSWER: Pelvic floor muscle training (PFMT) and pessaries are equally effective in treating symptoms of pelvic organ prolapse (POP...
Clinical Inquiries
Are topical nitrates safe and effective for upper extremity tendinopathies?
EVIDENCE-BASED ANSWER: Topical nitrates provide short-term relief with some side effects, especially headache. Topical nitroglycerin (NTG) patches...
Clinical Inquiries
Can yoga reduce symptoms of anxiety and depression?
EVIDENCE-BASED ANSWER: Yes, yoga can reduce symptoms of anxiety and depression (strength of recommendation [SOR]: B, systematic reviews of...
Clinical Inquiries
What is the best treatment for impetigo?
EVIDENCE-BASED ANSWER: Although evidence is lacking to support a single best treatment for impetigo, topical mupirocin, fusidic acid, gentamicin,...
Clinical Inquiries
Do complementary agents lower HbA1c when used with standard type 2 diabetes therapy?
EVIDENCE-BASED ANSWER: No, there is no high-quality evidence that supports using complementary or alternative agents to lower hemoglobin A1c (...
Clinical Inquiries
What are the benefits and risks of inhaled corticosteroids for COPD?
EVIDENCE-BASED ANSWER: Inhaled corticosteroids (ICS), either alone or with a long-acting β agonist (LABA), reduce the frequency of exacerbations...
Clinical Inquiries
How do hydrochlorothiazide and chlorthalidone compare for treating hypertension?
EVIDENCE-BASED ANSWER: Both medications reduce theincidence of cardiovascular events in patients with hypertension, but chlorthalidone may confer...
Clinical Inquiries
Which prophylactic therapies best prevent gout attacks?
EVIDENCE-BASED ANSWER: Allopurinol and febuxostat reduce the frequency of gout attacks equally after 8 weeks of treatment (strength of...
Clinical Inquiries
How can we effectively treat stress urinary incontinence without drugs or surgery?
EVIDENCE-BASED ANSWER: Pelvic floor muscle training (PFMT) and intravaginal electrical stimulation seem to be the best bets. PFMT increases...