Fluticasone Propionate Compared with Zafirlukast in Controlling Persistent Asthma A Randomized Double-Blind, Placebo-Controlled Trial

Conclusions

Treatment with FP 88 mg twice daily was more effective than zafirlukast 20 mg twice daily or placebo in improving asthma control and patient-rated outcomes in patients with persistent asthma who were previously receiving short-acting b2-agonists alone.

Acknowledgments

We acknowledge the important contributions made by the clinical investigators in this study: Thomas Bell, MD, Missoula, MT; Robert Berkowitz, MD, Atlanta, GA; David Bernstein, MD, Cincinnati, OH; Paul Chervinsky, MD, North Dartmouth, MA; Jonathan Corren, MD, Los Angeles, CA; David Coutin, MD, Bend, OR; David Denmead, MD, Danville, CA; James Fish, MD, Philadelphia, PA; Charles Fogarty, MD, Spartanburg, SC; Pinkus Goldberg, MD, Indianapolis, IN; Marshall P. Grodofsky, MD, West Hartford, CT; Jay Grossman, MD, Tucson, AZ; Alan Heller, MD, San Jose, CA; Harold Kaiser, MD, Minneapolis, MN; Edward Kent, MD, South Burlington, VT; Kathy Lampl, MD, Rockville, MD; Allen Lieberman, MD, Austin, TX; Richard Lockey, MD, Tampa, FL; Stephen McGeady, MD, Philadelphia, PA; Jon Musmand, MD, Portland, ME; Anjuli Nayak, MD, Normal, IL; Gregory Neagos, MD, Ypsilanti, MI; John Oppenheimer, MD, Springfield, NJ; Frank Picone, MD, Tinton Falls, NJ; Jacob Pinnas, MD, Tucson, AZ; Gordon Raphael, MD, Bethesda, MD; Guy Settipane, MD, Providence, RI; William Sokol, MD, Newport Beach, CA; James Taylor, MD, Tacoma, WA; Robert Townley, MD, Omaha, NE. We also acknowledge the assistance of Cheryl Beale, MA, and Richard A. Rogers, MS, in the preparation and editing of this manuscript. This study was supported by a grant from GlaxoWellcome Inc., Research Triangle Park, North Carolina.