Efficacy and Safety of New Dermal Fillers
Many dermal fillers are available for various cosmetic rejuvenation purposes including but not limited to treatment of facial rhytides, nasolabial folds (NLFs), facial volume deficits, and lipoatrophy; facial contouring; and lip and/or cheek augmentation. To update clinicians on best practices, we review the efficacy and safety data on the most recently approved dermal fillers.
Practice Points
- The merits of new dermal fillers approved by the US Food and Drug Administration should be weighed with an understanding of aesthetic indications of use, duration of efficacy, and common adverse effects, in line with patient preference.
- The most common adverse effects are injection-site contusion, swelling, and pain, usually self-resolving within days to 2 weeks. Patient quality of care can be improved with forewarning and emphasis on alleviating symptoms.
Conclusion
Several new options in dermal fillers have been approved in recent years and have demonstrated efficacy and acceptable safety in various cosmetic rejuvenation applications. Restylane Silk and Restylane Lyft are undergoing further studies to evaluate use in hand rejuvenation, an area that currently has few cosmetic filler treatment options. As technology continues to progress and new formulations of dermal fillers with varied properties and benefits are available, clinicians should expect multiple options for use in rhytides, volume deficits, and contouring.
ADDENDUM
After the manuscript was accepted for publication, Juvéderm Volbella XC (Allergan, Inc) was approved by the FDA for use in lip augmentation and thus is not included in this review.
