Distinct A1C and Blood Pressure Trajectories Found in T2DM
Key clinical point: Diabetes is associated with distinct temporal changes in HbA1c and systolic blood pressure.
Major finding: Four unrelated subgroups of patients were each identified with distinct trajectories of HbA1c and SBP over time.
Data source: The Dutch-based Diabetes Care System cohort of 9,849 patients with type 2 diabetes.
Disclosures: Dr. Nijpels and Dr. Walraven had no conflicts of interest.
AT EASD 2014
When the delayed responders were compared with the adequate responders, they tended to be older (66 vs. 59 years) and have higher body mass indexes (31 kg/m2 vs. 29 kg/m2). The insufficient responders were also older and had higher body weight, and were also more likely to be female than male (68% vs. 47%), compared with the adequate responders). Nonresponders were also more likely to be women, of older age, and have a longer diabetes duration (2 vs. 0.9 years).
Dr. Walraven reported that patients with insufficient SBP control had almost a twofold increased risk for cardiovascular disease. “Subgroups with inferior SBP control are important to target in order to eventually improve BP management,” she observed.
Patients’ adherence to medication was questioned in the discussions following both presentations. Although this was not directly measured, Dr. Nijpels responded that, certainly with regard to glucose-lowering agents, that he was “convinced that everyone in this cohort took their medication.”
Dr. Nijpels and Dr. Walraven had no conflicts of interest.
