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Inhibitor produces high response rate in relapsed/refractory FL
CHICAGO – The PI3K-delta inhibitor ME-401, given with or without rituximab, produced an overall response rate of 80% in a phase 1b trial of...
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Olanzapine improves upon standard antiemetic therapy
CHICAGO – Complete response rates were higher among patients who received olanzapine plus standard therapy.
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Pembrolizumab improves 5-year OS in advanced NSCLC
CHICAGO – In a phase 1b trial of pembrolizumab, the 5-year OS rate was 23.2% in treatment-naive patients and 15.5% in previously treated patients...
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SC-PEG comparable to pegaspargase in young ALL/LL patients
CHICAGO – Patients who received SC-PEG had similar serum asparaginase activity, toxicities, and survival as patients...
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Combo produces ‘best response rate’ after first relapse in kids with AML
CHICAGO – CPX-351 followed by fludarabine, cytarabine, and filgrastim produced an overall response rate of 81%.
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Trial matches pediatric cancer patients to targeted therapies
Nearly a quarter of the patients screened as part of the National Cancer Institute–Children’s Oncology Group Pediatric MATCH trial have been...
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Entrectinib exhibits activity in children with solid tumors
Entrectinib produced responses in patients who had fusions or mutations in target genes.
Article
NCCN and MD Anderson award funding to researchers
Four researchers won funding via the NCCN Young Investigator Awards, and eight researchers will receive funding from the Andrew Sabin Family...
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NGS comparable to FC for minimal residual disease assessment
NEW ORLEANS – NGS of peripheral blood proved at least as effective as flow cytometry for assessing MRD in children and young adults with B-ALL who...
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Low-dose chemo feasible for older, frail patients with advanced gastroesophageal cancer
The lowest dose of oxaliplatin and capecitabine proved noninferior to two higher doses in a study of older and frail patients with advanced...
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Lenalidomide may reduce risk of progression from SMM to MM
At 3 years, the rate of progression-free survival was 91% in patients with smoldering multiple myeloma who were randomized to lenalidomide and 66...
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Diet linked to lower risk of death from breast cancer
A balanced, low-fat diet was associated with a 21% lower risk of death from breast cancer in a randomized study.
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QOL concerns prompt second-line therapy in children with ITP
NEW ORLEANS – Quality of life was the most common reason for starting second-line therapy in a cohort of children with immune thrombocytopenia.
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Master trial seeks to aid drug development for pediatric AML
NEW ORLEANS – “What we see in childhood AML is a lot different than what we see in adult AML, and this challenges the paradigm that we have...
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Next-generation sequencing test detects pathogens with high sensitivity
NEW ORLEANS – The test detected pathogens with 92% sensitivity, which was more sensitive than conventional testing methods.