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Brian F. Mandell, MD, PhD

Article

Off-label and oft-prescribed

Author:
Brian F. Mandell, MD, PhD

When prescribing drugs for uses beyond their FDA indications, we need to explain their anticipated side effects and benefits.

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Article

A link between A-fib and sleep apnea is no surprise, but why?

Author:
Brian F. Mandell, MD, PhD

The two conditions commonly coexist, and treating the sleep apnea results in better rhythm-directed outcomes in the A-fib.

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Article

A few pearls can help prepare the mind

Author:
Brian F. Mandell, MD, PhD

The caregiver with a prepared mind is more likely to experience the diagnostic epiphany.

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Article

Clinical outcomes in diabetes: It’s not just the glucose (and it’s not so simple)

Author:
Brian F. Mandell, MD, PhD

As we dig deeper into the reduction in cardiovascular deaths seen with some newer drugs, several questions arise.

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Article

Deciding when a picture is worth a thousand words and several thousand dollars

Author:
Brian F. Mandell, MD, PhD

Physical examination is cheap but not highly reproducible. Imaging is expensive but may be more sensitive and specific.

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Article

Clinical trials: More to learn than the results

Author:
Brian F. Mandell, MD, PhD

The details of the GIACTA trial challenge and reaffirm some of our clinical impressions about giant cell arteritis.

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Article

The return of measles—an unnecessary sequel

Author:
Brian F. Mandell, MD, PhD

Why are we having such a tough time convincing people to get routine vaccines for themselves and for their kids?

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Article

Infection or not infection, that is the question—Is procalcitonin the answer?

Author:
Brian F. Mandell, MD, PhD

What is it about procalcitonin that allows it to succeed as a biomarker where CRP and the ESR fail?

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Article

Can a humanities background prevent physician burnout?

Author:
Brian F. Mandell, MD, PhD

Osler urged physicians to study the humanities. Can it prevent professional dissatisfaction and burnout?

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Article

The tests that we order define us

Author:
Brian F. Mandell, MD, PhD

In practice we balance the inputs from Watson, “Dr. Google,” our experience, and the specific data from the patient.

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Article

There is more to the TSH than a number

Author:
Brian F. Mandell, MD, PhD

Management of subclinical hypothyroidism should be nuanced and based on both clinical and laboratory parameters.

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Article

MGUS: It’s about the protein, not just the marrow

Author:
Brian F. Mandell, MD, PhD

What is a cause of a high erythrocyte sedimentation rate with a normal C-reactive protein and a low anion gap?

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Article

A new reason to reconsider that antibiotic prescription: The microbiome

Author:
Brian F. Mandell, MD, PhD

The impact of antibiotics on the gut microbiome may be implicated in the rise in obesity and diabetes.

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Article

A physician’s response to observational studies of opioid prescribing

Author:
Brian F. Mandell, MD, PhD

Not long ago, we were told we needed to do better at relieving pain.

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Article

Small fibers, large impact

Author:
Brian F. Mandell, MD, PhD

The wide interest in small fiber neuropathy may reflect our current apparent epidemic of chronic pain.

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