Article

Off-label and oft-prescribed
- Author:
- Brian F. Mandell, MD, PhD
When prescribing drugs for uses beyond their FDA indications, we need to explain their anticipated side effects and benefits.
Article

A link between A-fib and sleep apnea is no surprise, but why?
- Author:
- Brian F. Mandell, MD, PhD
The two conditions commonly coexist, and treating the sleep apnea results in better rhythm-directed outcomes in the A-fib.
Article

A few pearls can help prepare the mind
- Author:
- Brian F. Mandell, MD, PhD
The caregiver with a prepared mind is more likely to experience the diagnostic epiphany.
Article

Clinical outcomes in diabetes: It’s not just the glucose (and it’s not so simple)
- Author:
- Brian F. Mandell, MD, PhD
As we dig deeper into the reduction in cardiovascular deaths seen with some newer drugs, several questions arise.
Article

Deciding when a picture is worth a thousand words and several thousand dollars
- Author:
- Brian F. Mandell, MD, PhD
Physical examination is cheap but not highly reproducible. Imaging is expensive but may be more sensitive and specific.
Article

Clinical trials: More to learn than the results
- Author:
- Brian F. Mandell, MD, PhD
The details of the GIACTA trial challenge and reaffirm some of our clinical impressions about giant cell arteritis.
Article

The return of measles—an unnecessary sequel
- Author:
- Brian F. Mandell, MD, PhD
Why are we having such a tough time convincing people to get routine vaccines for themselves and for their kids?
Article

Infection or not infection, that is the question—Is procalcitonin the answer?
- Author:
- Brian F. Mandell, MD, PhD
What is it about procalcitonin that allows it to succeed as a biomarker where CRP and the ESR fail?
Article

Can a humanities background prevent physician burnout?
- Author:
- Brian F. Mandell, MD, PhD
Osler urged physicians to study the humanities. Can it prevent professional dissatisfaction and burnout?
Article

The tests that we order define us
- Author:
- Brian F. Mandell, MD, PhD
In practice we balance the inputs from Watson, “Dr. Google,” our experience, and the specific data from the patient.
Article

There is more to the TSH than a number
- Author:
- Brian F. Mandell, MD, PhD
Management of subclinical hypothyroidism should be nuanced and based on both clinical and laboratory parameters.
Article

MGUS: It’s about the protein, not just the marrow
- Author:
- Brian F. Mandell, MD, PhD
What is a cause of a high erythrocyte sedimentation rate with a normal C-reactive protein and a low anion gap?
Article

A new reason to reconsider that antibiotic prescription: The microbiome
- Author:
- Brian F. Mandell, MD, PhD
The impact of antibiotics on the gut microbiome may be implicated in the rise in obesity and diabetes.
Article

A physician’s response to observational studies of opioid prescribing
- Author:
- Brian F. Mandell, MD, PhD
Not long ago, we were told we needed to do better at relieving pain.
Article

Small fibers, large impact
- Author:
- Brian F. Mandell, MD, PhD
The wide interest in small fiber neuropathy may reflect our current apparent epidemic of chronic pain.