Clarifying a statement about efficacy of FGA, SGA

We appreciate Dr. Nasrallah referencing our work to assert that “most SGAs are similar to FGAs.” (Current Psychiatry, Comments & Controversies, October 2013, p. 39-40; https://bit.ly/177QOy6). What we actually found in our 2003¹ and 2011² meta-analyses was that “some antipsychotics are more efficacious than others,” and the first-generation antipsychotic vs second-generation antipsychotic distinction is not very useful clinically.³ These findings have repeatedly been replicated.³

John M. Davis, MD
Professor
Department of Psychiatry
University of Illinois at Chicago
Chicago, Illinois

Ira D. Glick, MD
Professor Emeritus of Psychiatry and Behavioral Sciences
Department of Psychiatry
Stanford University School of Medicine
Stanford, California