Clinical Edge

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Antidepressant Use Among Reproductive-Aged Women

Prescription claims studied

The use of certain antidepressants during early pregnancy is possibly associated with the occurrence of some major birth defects, and from 2008 to 2013, approximately 15% of a convenience sample of reproductive-aged women in the US aged 15 to 44 years with employer-sponsored insurance filled a prescription for antidepressants. An average of 5.8 million women were included in the analytic sample each year of the study. Researchers found:

• The most commonly filled antidepressants were sertraline, bupropion, and citalopram.

• Women aged 35 to 44 years accounted for the largest proportion of reproductive-aged women filling prescriptions for all common antidepressant types.

• Overall, the percentage of reproductive-aged women with antidepressant claims remained relatively stable during 2008 to 2013; however, prescription claims for some antidepressants showed modest variability.

Citation: Dawson AL, Ailes EC, Gilboa SM, et al. Antidepressant prescription claims among reproductive-aged women with private employer-sponsored insurance – United States 2008-2013. MMWR Morb Mortal Wkly Rep 2016;65:41–46. doi: