Clinical Edge Journal Scan

Altered adipokine levels in pregnant women with severe preeclampsia


Key clinical point: The maternal blood and umbilical cord serum leptin, visfatin, and spexin levels were significantly altered in nondiabetic pregnant women with vs without preeclampsia, with leptin and visfatin levels showing a significant and positive correlation with maternal body mass index (BMI) in women with and without preeclampsia.

Major finding: Pregnant women with vs without severe preeclampsia had significantly higher levels of serum leptin and visfatin (P < .001) and lower levels of spexin (P < .001) in both maternal blood and umbilical cord, with maternal BMI and leptin and visfatin levels in maternal blood and umbilical cord being positively correlated in women with (P < .001) and without (P < .01) severe preeclampsia.

Study details: This was a case-control observational study including 45 pregnant women with severe preeclampsia and 45 gestational age-matched women with normal pregnancies without known medical conditions, who underwent a cesarean section at 34-35 weeks of gestation.

Disclosures: This study did not report the source of funding. The authors declared no conflicts of interest.

Source: Gök S et al. Evaluation of the adipokine levels of pregnant women with preeclampsia. J Obstet Gynaecol Res. 2022 (Oct 13). Doi: 10.1111/jog.15463

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