Change in leiomyoma size during pregnancy not as prominent as commonly thought

Key clinical point: The size of uterine leiomyoma commonly increases before 22-24 gestational weeks, with the growth being fastest before 11-14 weeks. The size remained almost unchanged from 22-24 weeks to the predelivery gestational weeks.

Major finding: The change in leiomyoma diameter from weeks 6-7 to 11-14, 11-14 to 22-24, 22-24 to 28-34, and 28-34 to predelivery gestational weeks was 0.767 cm, 0.367 cm, −0.133 cm, and −0.100 cm, respectively, with the difference between gestational intervals being statistically significant (P < .05). Overall, leiomyoma increased by 23.99% between weeks 6-7 to predelivery gestational weeks, with growth being highest between weeks 6-7 and 11-14 (9.92%).

Study details: Findings are from a prospective cross-sectional study including 394 pregnant women with uterine leiomyoma.

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Disclosures: The study was funded by the Beijing Municipal Science & Technology Commission and Beijing Obstetrics and Gynecology Hospital. The authors declared no conflict of interests.

Source: Tian Y C et al. Int J Gynaecol Obstet. 2021 Aug 27. doi: 10.1002/ijgo.13903.