Chromosomal Regions Associated With Late-onset Alzheimer Disease

Which areas may prove causative?

October 20, 2015|Neurology

There are 2 chromosomal regions that may harbor familial late-onset Alzheimer disease (LOAD) causative mutations, according to a study of 282 families of Caribbean Hispanic descent, including 67 with LOAD. Researchers found:

• There are at least 26 regions linked to LOAD.

• 13 of the regions were validated using the entire family sample.

• The strongest signal was at 11q12.3 a locus located ∼2 Mb upstream of the membrane-spanning 4A gene cluster.

• There is also a locus at 7p14.3, a region harboring genes associated with the nervous system.

Citation: Barral S, Cheng R, Reitz C, et al. Linkage analyses in Caribbean Hispanic families identify novel loci associated with familial late-onset Alzheimer's disease. [Published online ahead of print September 30, 2015]. Alzheimers Dement. doi: 10.1016/j.jalz.2015.07.487.

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