Morbo Serpentino

• Syphilis, the great imposter, is rising in incidence and should be on the differential diagnosis in all patients with unexplained multisystem inflammatory disease.
• A cost-effective diagnostic approach to syphilis entails serologic testing with treponemal and nontreponemal assays.
• Unexplained granulomas, especially in the skin, bone, or liver, should prompt consideration of gummatous syphilis.
• Ocular syphilis may involve any part of the visual tract and is treated the same as neurosyphilis.

Disclosure

Dr. Weinreich has received payment for lectures from Boehringer er Ingelheim, Astra Zeneca, TEVA and Novartis in 2016. All other contributors have nothing to report.