Anti-TNFs for ulcerative colitis up sepsis risk after some proctocolectomies

Of the 407 patients whose initial surgery was STC with end ileostomy, 35% were receiving anti-TNF agents preoperatively.

Within this group, patients taking anti-TNF agents preoperatively did not have an elevated risk of any of the complications studied at either 30 days or 1 year. The findings were similar among the subset who went on to have a completion proctectomy and ileoanal pouch–anal anastomosis.

Dr. Gu and Dr. Kiran both disclosed no relevant financial conflicts.