From the Journals

COVID vaccines safe for young children, study finds




COVID-19 vaccines from Moderna and Pfizer-BioNTech are safe for children under age 5 years, according to findings from a study funded by the Centers for Disease Control and Prevention.


  • Data came from the Vaccine Safety Datalink, which gathers information from eight health systems in the United States.
  • Analyzed data from 135,005 doses given to children age 4 and younger who received the Pfizer-BioNTech , and 112,006 doses given to children aged 5 and younger who received the Moderna version.
  • Assessed for 23 safety outcomes, including myocarditis, pericarditis, and seizures.


  • None of the adverse outcomes, including myocarditis or pericarditis, was detected among the children in the 21 days following receipt of either vaccine.
  • One case of hemorrhagic stroke and one case of pulmonary embolism occurred after vaccination but these were linked to preexisting congenital abnormalities.


“These results can provide reassurance to clinicians, parents, and policymakers alike.”


The study was led by Kristin Goddard, MPH, a researcher at the Kaiser Permanente Vaccine Study Center in Oakland, Calif., and was funded by the Centers for Disease Control and Prevention.


The researchers reported low statistical power for early analysis, especially for rare outcomes. In addition, fewer than 25% of children in the database had received a vaccine at the time of analysis.


A coauthor reported receiving funding from Janssen Vaccines and Prevention for a study unrelated to COVID-19 vaccines. Another coauthor reported receiving grants from Pfizer in 2019 for clinical trials for coronavirus vaccines, and from Merck, GSK, and Sanofi Pasteur for unrelated research.

A version of this article first appeared on

Recommended Reading

Hyperbaric oxygen may improve heart function in long COVID
MDedge Infectious Disease
How providers are adjusting to clinical care post PHE
MDedge Infectious Disease
CDC cuts back hospital data reporting on COVID
MDedge Infectious Disease
COVID emergency over, but hundreds are still dying weekly
MDedge Infectious Disease
Review supports continued mask-wearing in health care visits
MDedge Infectious Disease
COVID boosters effective, but not for long
MDedge Infectious Disease
Study finds COVID-19 boosters don’t increase miscarriage risk
MDedge Infectious Disease
One in 10 people who had Omicron got long COVID: Study
MDedge Infectious Disease
COVID nonvaccination linked with avoidable hospitalizations
MDedge Infectious Disease
We may need a new defense against new COVID variants
MDedge Infectious Disease