Team devises novel fluorescence microscopy technique

Although other methods have been used to capture multiple views sequentially, the researchers said this new method improves spatial resolution without introducing additional illumination or compromising temporal resolution relative to conventional imaging.

This is important because additional light can be damaging and even deadly to living cells, and the temporal resolution is needed to capture fast processes.

The researchers are now exploring additional biological applications for the new system and are working to extend the method to other microscope modalities, such as confocal microscopy.