How genetics, race affect clopidogrel outcomes

Research examining how genetic variants alter the effectiveness of clopidogrel remains somewhat controversial, Dr Bach said. Many physicians feel that before they can tailor therapy for heart attack patients, more data is needed to prove a clear link between genetic variants and negative health consequences and that tailoring therapy will improve patients’ outcomes, he explained.

His hope is that additional research would provide more definitive conclusions to help physicians choose the best medications for patients after a heart attack and, ultimately, “to reduce the too-high rate of death and disability for patients after a heart attack,” Dr Bach said.

Dr Cresci agreed, adding, “By focusing on genetic differences, we may be able to individualize therapies after heart attacks and achieve the best treatment for each patient.”