In Tackling Type 2 Diabetes in Teens, Think Outside the Box

▸ Sulfonylureas. Accentuated side effects in teens, especially hypoglycemia and weight gain, greatly limit their value. “I don't use them anymore,” Dr. Zeitler said.

▸ Metaglinide analogs. These short-acting insulin secretagogues are in theory helpful in controlling postprandial hyperglycemia, but they have to be taken before meals and “compliance in these kids is generally horrendous,” he said.