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Acute-on-chronic itch is new frontier in atopic dermatitis
Research attention is focusing on role of circulating IgE-activated basophils.
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Novel topical acne combo hits marks in phase 3 trials
The fixed-dose combination of benzoyl peroxide and tretinoin is under FDA review.
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Daily sunscreen use will prevent more melanoma deaths than early detection
“Prevention is low cost, low risk, and effective.”
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International expert group agrees on redefining psoriasis severity
“What we came up with is a very sensible approach to defining whether patients should get either topical or systemic therapy.”
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The case for anti–IL-17 agents as first-line biologics in psoriatic arthritis
“The guidelines don’t give full credit to the anti–IL-17 agents.”
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Expanded indications likely for apremilast
“My prediction is apremilast will have efficacy in children and teenagers comparable to what it has in adults.”
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Merino wool clothing improves atopic dermatitis, studies find
In one study, the mean Eczema Area and Severity Index score in those initially randomized to merino wool improved from a mean baseline of 4.5 to 1...
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Potential new option: 1-month DAPT post DES, then aspirin alone
The One-Month DAPT trial swapped aspirin monotherapy for prolonged P2Y12 inhibition.
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Mitotic rate makes comeback as melanoma prognosticator
Key insight: the relationship between mitotic rate and melanoma survival is nonlinear.
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Improvements in chronic hand eczema seen with oral gusacitinib in phase 2 study
The rapidity of response was noteworthy in these steroid-refractory patients.
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Tildrakizumab for psoriasis shows durable efficacy over 5 years
Few left long-term extension study because of adverse events or loss of efficacy.
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Inattention to heightened CV risk common theme in clozapine deaths teaser
“Inadequate treatment for metabolic syndrome was found to be a mortality predictor while on clozapine therapy,” said Dr. Sharon Taub.
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New-onset AFib common but unrecognized in the month after cardiac surgery
Results of SEARCH-AF trial show one in five cardiac surgery patients with no history of atrial fibrillation develop it within 30 days post...
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Siblings of patients with bipolar disorder at increased risk
“Strategies to prevent onset of psychiatric illness in individuals with a first-generation family history ... should be lifelong,” said Dr. Lars...
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Chronic inflammatory diseases vary widely in CHD risk
The highest coronary heart disease risks linked to inflammation are seen in SLE and systemic sclerosis, conditions that aren’t included in...