Clinical Edge

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Signs of adult diabetes apparent in very young children

Key clinical point: Disturbed HDL cholesterol metabolism may be one of the earliest features of type 2 diabetes.

Major finding: Children as young as 8 years old exhibit changes in HDL cholesterol that may predispose them to developing type 2 diabetes in later life.

Study details: A cohort study linking genetic liability with repeated metabolomic data from 4,761 offspring from the Avon Longitudinal Study of Parents and Children cohort.

Disclosures: The study was funded by Diabetes U.K., Cancer Research U.K., the Elizabeth Blackwell Institute for Health Research, the Wellcome Trust, the Medical Research Council, and the University of Bristol. Dr. Bell had no conflicts of interest to declare.


Bell J et al. bioRxiv. 2019 Sep 17. doi: 10.1101/767756