Calcium Hydroxylapatite Filler Foreign Body Granulomas: A Case Report of a Rare Occurrence and Review of the Literature

Calcium hydroxylapatite (CaHA) is approved by the US Food and Drug Administration for the correction of wrinkles and folds such as the nasolabial folds and human immunodeficiency virus–associated lipodystrophy. We report a rare case of foreign body granuloma formation in a 47-year-old woman who developed a persistent nodule on the left side of the upper lip following injection with CaHA in the lower face. We also discuss potential etiologies for this unpredictable reaction.