IM Board Review
Gaucher disease causes hepatomegaly, splenomegaly, bone marrow disease, bone pain, bone infarcts, and lytic lesions.
E-cigarettes have never been subjected to any kind of testing of safety or of efficacy as nicotine replacement therapy.
Botulinum toxin is approved for neurogenic detrusor overactivity and overactive bladder refractory to drug therapy.
Certain populations have special vaccination needs and contraindications, which the authors review.
Guidelines exist, but so do uncertainties.
In women in their 40s, the incidence of breast cancer is low but the risk of a tumor being aggressive is especially high.
In view of the potential harm, we question annual screening starting at age 40.
Can the test for human papillomavirus DNA be used as the stand-alone, first-line screening test for cervical cancer?
Yes. The FDA has approved the test for this indication, and guideline committees are reviewing the data.
Severe alcoholic hepatitis is a devastating acute condition that requires early recognition and specialized tertiary medical care.
Before dispensing advice, we should know the effect of whatever we are recommending on all meaningful outcomes.