Proceedings of the 2008 Heart-Brain Summit


Supplement Editor:
Marc S. Penn, MD, PhD


Earl E. Bakken, MD, HonC, Hon DSc (3), Hon DHL (2)

Introduction: Heart-brain medicine: Update 2008
Marc S. Penn, MD, PhD, and Earl E. Bakken, MD, HonC, Hon DSc (3), Hon DHL (2)

Bakken Lecture: The brain, the heart, and therapeutic hypothermia
Patrick M. Kochanek, MD

Session 1: Pathways Involved in Neuromodulation of Risks in Coronary Artery Disease

Depression and heart rate variability in patients with coronary heart disease
Robert M. Carney, PhD, and Kenneth E. Freedland, PhD

Autonomic function and prognosis
Michael S. Lauer, MD

Vagal tone and the inflammatory reflex
Julian F. Thayer, PhD

Inflammation, atherosclerosis, and arterial thrombosis: Role of the scavenger receptors CD36
Roy L. Silverstein, MD

Pioneer Award Address: Ignorance isn't biased: Comments on receiving the Pioneer Award
David S. Goldstein, MD, PhD

Session II: Measures and Strategies for Modulation of Heart-Brain Interactions

Heart rate variability with deep breathing as a clinical test of cardiovagal function
Robert W. Shields, Jr, MD

Basic research models for the study of underlying mechanisms of electrical neuromodulation and ischemi heart-brain interactions
Mike J.L. DeJongste, MD, PhD, FESC; Gert J. TerHorst, PhD; and Robert D. Foreman, PhD

Session III: Annual Review of Key Papers in Heart-Brain Medicine

Key papers in the field published during the year prior to the Summit were discussed; two of those papers are reported here.

Cardiac sympathetic denervation preceding motor signs in Parkinson disease
David S. Goldstein, MD, PhD; Yehonatan Sharabi, MD; Barbara I. Karp, MD; Oladi Bentho; Ahmed Saleem, MD; Karel Pacak, MD, PhD; and Graeme Eisenhofer, PhD

Supine low-frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic innervation
Jeffrey P. Moak, MD; David S. Goldstein, MD, PhD; Basil A. Eldadah, MD, PhD; Ahmed Saleem, MD; Courtney Holmes, CMT; Sandra Pechnik, RN; and Yehonatan Sharabi, MD

Session IV: Code Lavender—Strategies for Implementing Heart-Brain Medicine

Is posttraumatic stress disorder related to development of heart disease? An update
Laura D. Kubzansky, PhD, and Karestan C. Koenen, PhD

Creating a healing environment: Rationale and research overview
Jone Geimer-Flanders, DO

Redesigning the neurocritical care unit to enhance family participation and improve outcomes
Owen Samuels, MD

Session V: Insights into Neuromodulation of Cardiovascular Function

Neuromodulation of cardiac pain and cerebral vasculature: Neural mechanisms
Robert D. Foreman, PhD, and Chao Qin, MD, PhD

Pinacidil induces vascular dilation and hyperemia in vivo and does not impact biophysical properties of neurons and astrocytes in vitro
Rosa Cao; Bryan T. Higashikubo; Jessica Cardin; Ulf Knoblich; Raddy Ramos, PhD; Mark T. Nelson, PhD; Christopher I. Moore, PhD; and Joshua C. Brumberg, PhD

The polyvagal theory: New insights into adaptive reactions of the autonomic nervous system
Stephen W. Porges, PhD

Poster Abstracts

Abstract 1: Insulin use does not protect against restenosis in diabetic patients presenting with acute coronary syndrome or symptomatic angina
Matthew C. Becker, MD; John M. Galla, MD; Saif Anwaruddin, MD; Samir Kapadia, MD; and Richard A. Krasuski, MD

Abstract 2: Postoperative statin use and lower LDL cholesterol concentration are associated with reduced incidence of stroke
Matthew C. Becker, John M. Galla, Ryan P. Daly, Femi Philip, Peter Zimbwa, Stephen O. Chen, Chen H. Chow, Tingfei Hu, Richard A. Krasuski, and Arman T. Askari

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