HT Staff

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Idelalisib more effective in CLL, iNHL than MCL

Author:: HT Staff

Publish date: March 11, 2014

Credit: FDA Results of a phase 1 study suggest the PI3K delta inhibitor idelalisib can produce durable responses in certain patients with relapsed ...

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Team uses DNA methylation to quantify leukocytes

Author:: HT Staff

Publish date: March 11, 2014

Credit: Graham Colm Investigators have found they can use DNA methylation to simultaneously count multiple leukocyte subsets in blood samples, and ...

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Rate of protein synthesis affects HSC function, study suggests

Author:: HT Staff

Publish date: March 10, 2014

in the bone marrow Hematopoietic stem cells (HSCs) require a highly regulated rate of protein synthesis to function properly, according to research...

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Score can predict survival in GVHD patients

Author:: HT Staff

Publish date: March 9, 2014

Credit: CDC A scoring system that rates symptoms of pulmonary dysfunction can help predict survival in patients with chronic graft-vs-host disease ...

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Mutant B-cell progenitor causes leukemia, group finds

Author:: HT Staff

Publish date: March 8, 2014

Credit: Aaron Logan Researchers have identified a cell that appears to be responsible for a particularly aggressive type of leukemia in mice. Th...

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Pathway may drive treatment resistance in T-ALL

Author:: HT Staff

Publish date: March 7, 2014

Experiments in zebrafish have revealed a mechanism that may drive relapse in human T-cell acute lymphoblastic leukemia (T-ALL). Researchers identif...

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Warmer temperatures push malaria to higher elevations

Author:: HT Staff

Publish date: March 7, 2014

Credit: Asnakew Yeshiwondim Researchers say they have the first hard evidence that malaria creeps to higher elevations during warmer years and retr...

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Why genetic screening isn’t preventing SCD

Author:: HT Staff

Publish date: March 7, 2014

and a normal one Credit: Betty Pace There may be a simple reason why genetic screening has failed to fulfill the promise of preventing sickle cell...

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Nanoparticle therapy active in B-cell malignancies

Author:: HT Staff

Publish date: March 6, 2014

An experimental nanoparticle therapy has shown preclinical activity against a range of B-cell malignancies, researchers have reported. The therapy,...

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England’s Cancer Drugs Fund raises concerns

Author:: HT Staff

Publish date: March 6, 2014

Credit: Rhoda Baer Cancer patients in England are more likely to receive prescriptions for expensive drugs than patients in Wales, according to a s...

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Histones’ role in gene regulation

Author:: HT Staff

Publish date: March 5, 2014

Credit: Eric Smith Researchers say they’ve discovered how histones control PARP1’s ability to activate genes and repair DNA damage. Their findin...

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Palliative chemo can have undesired outcomes

Author:: HT Staff

Publish date: March 5, 2014

Credit: Rhoda Baer Palliative chemotherapy can negatively impact the end of life for terminally ill cancer patients, according to a paper published...

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Neutropenia prophylaxis, incidence increase with age

Author:: HT Staff

Publish date: March 4, 2014

Credit: Volker Brinkmann New research suggests that older non-Hodgkin lymphoma patients are more likely than their younger counterparts to receive ...

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Drugs get orphan designation for AML, MM

Author:: HT Staff

Publish date: March 4, 2014

Credit: FDA The US Food and Drug Administration (FDA) has granted orphan designation for the histone deacetylase (HDAC) inhibitor pracinostat to tr...

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New approach for treating PNH

Author:: HT Staff

Publish date: March 2, 2014

Investigators have identified a novel strategy for treating paroxysmal nocturnal hemoglobinuria (PNH), according to a paper published in Blood. In ...