Screening Using HbA_1c Misclassifies Many

The prevalence of diabetes increased in a stepwise fashion with increasing BMI, from 1.5% among those with a normal BMI (18.5-24.9) to 15% among those who met criteria for class III obesity (BMI more than 40). “For every 1 unit increase in BMI, we observed a 10% increase in the odds of having diabetes,” she said.

Ms. Jackson also reported that with the IEC, ADA, and VA/DoD cutoffs for diabetes, screening with HbA_1c was specific but insensitive, with a false-negative rate of 68% at the 6.5% cutoff and a false-negative rate of 89% at the 7.0% cutoff.

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Source Elsevier Global Medical News