EASD: High A1C Linked to Elevated Dementia Risk in Patients With T2DM
Key clinical point: Lowering HbA1cand good general diabetes risk-factor control may help prevent dementia in patients with type 2 diabetes.
Major finding: HbA1c ≥10% increased the risk for dementia by 23% in time-fixed analysis and by 73% in time-updated analysis.
Data source: More than 353,000 patients with type 2 diabetes followed for a mean of 4.8 years for the development of dementia, death, or end of follow-up in 2012.
Disclosures: Dr. Rawshani did not report having any disclosures. Dr. Sattar said he had no disclosures relevant to his comments.
AT EASD 2015
“The study showed clearly that high BMI, high LDL, and high blood pressure were also associated with more dementia,” Dr. Sattar said. “And, it also showed that being on antihypertensives and cholesterol-lowering tablets gives you a low risk of dementia,” he added. “So the things we are doing in diabetes to keep blood pressure down, smoking down, cholesterol down, are working and, together with keeping hemoglobin in the normal range, should help to lower the risk of dementia. That’s epidemiology, and we now need the trials to prove it, but it’s going to be very, very tough.”
Dr. Rawshani did not report having any disclosures. Dr. Sattar said that he had no disclosures relevant to his comments.
