Late-life depressive symptoms may partially mediate the association of subclinical cardiovascular disease (CVD) with mild cognitive impairment (MCI)/dementia onset, a recent study found. Among participants from the Cardiovascular Health Study Cognition Study who did not have baseline CVD-related events (n=2,450), causal mediation methodology was implemented to examine whether late-life depressive symptoms, defined as 10-item Center for Epidemiologic Studies-Depression Scale scores ≥8 from 2-3 years after baseline, partially mediated the association of baseline subclinical CVD (CAC, carotid intimal medial thickness, stenosis, and ankle brachial index) with MCI/dementia onset occurring between 5-10 years from baseline. Researchers found:
- Participants contributed 20,994 person-years of follow-up with a median follow-up time of 9.4 years.
- Subclinical CVD was associated with 12% faster time to MCI/dementia.
- The total effect of subclinical CVD on MCI/dementia onset was decomposed into a direct effect and indirect effect.
- 64.5% of the total effect was mediated by late-life depressive symptoms.
Armstrong NM, Carlson MC, Schrack J, et al. Late-life depressive symptoms as partial mediators in the associations between subclinical cardiovascular disease with onset of mild cognitive impairment and dementia. [Published online ahead of print November 20, 2017]. Am J Gertiatr Psychiatry. doi:10.1016/j.jagp.2017.11.004.
This Week's Must Reads
Folic Acid Exposure Linked with Psychosis Reduction, JAMA Psychiatry; ePub 2018 Jul 3; Eryilmaz, et al
Increasing Trend of Naloxone Use in the US, Addiction; ePub 2018 Jul 10; Rege, Ngo, et al
Antipsychotic Use Examined Across Wide Age Range, Int J Geriatr Psych; ePub 2018 Jul 8; Jester, et al
FDA Approves New Dosing Formulation for Nuplazid, Acadia Pharmaceuticals Inc. news release; 2018 Jun 29
Midlife Fitness Linked with Lower Depression Risk , JAMA Psychiatry; ePub 2018 Jun 27; Willis, et al
Must Reads in Alzheimer's & Cognition
Widowhood a Risk Factor for Cognitive Decline, Am J Geriatr Psychiatry; ePub 2018 Mar 26; Shin, et al
Caregivers of PLWDs at Risk for Sleep Disturbances, Am J Geriatr Psych; ePub 2018 Feb 4; Polenick, et al
Study: Goal-driven Life Reduces Dementia Risk, Int J Geriatr Psych; ePub Jan 3; Sutin, et al
Walking While Talking and Incident Dementia Risk, Am J Geriatr Psychiatry; ePub 2018 Jan 3; Ceïde, et al
CVD, Late-Life Depression, Dementia Link Examined, Am J Geriatr Psychiatry; ePub 2017 Nov 20; Armstrong, et al