Clinical Progress Note: High Flow Nasal Cannula Therapy for Bronchiolitis Outside the ICU in Infants

Many children’s hospitals have extended the use of HFNC outside the ICU for children with bronchiolitis despite the paucity of evidence demonstrating its benefit over standard flow oxygen. Given variation in protocols, study designs, outcomes, and number of patients studied, it is difficult to assess its efficacy outside the ICU. However, based on the studies reviewed herein, HFNC therapy does not appear to decrease LOS, time on oxygen, or escalations of care, such as ICU transfers, positive pressure ventilation, or intubation, when used as a primary therapy.^7,9,11,12 Future research will ideally use optimal flow rates to determine the effectiveness of HFNC on acute care units. Although not addressed in the above studies, additional benefits to be considered in future studies include: (1) increased critical care capacity by allowing patients to be supported on the floor and (2) the ability for patients to remain closer to home when HFNC is used in the community hospital setting.

In each of the large, randomized studies reviewed, most (66%-75%) patients treated with standard low flow oxygen were supported successfully and did not require escalation to HFNC.^9,10 Hospitalists should continue to use standard low flow oxygen as first-line respiratory support for patients with bronchiolitis.¹ No evidence supports the use of HFNC therapy early in a child’s inpatient course; rather, it should be used when standard oxygen therapy fails. Future research should focus on better elucidating which patients will benefit most from HFNC to prevent overuse.