Treatment of Pediatric Venous Thromboembolism
GUIDELINE TITLE: American Society of Hematology 2018 Guidelines for the management of venous thromboembolism: treatment of pediatric venous thromboembolism
DEVELOPER: The American Society of Hematology multidisciplinary subcommittee
RELEASE DATE: November 27, 2018
FUNDING SOURCE: American Society of Hematology
PRIOR VERSION: N/A
TARGET POPULATION: less than 18 years of age
© 2019 Society of Hospital Medicine
AREAS IN NEED OF FUTURE STUDY
Although there is increasing interest in pediatric VTE prevention and risk assessment,7 there is currently limited evidence on the best ways to mitigate VTE risk or anticoagulation-associated major bleeding in hospitalized children. The relatively low incidence of VTE in children makes large randomized controlled trials difficult, but several are ongoing. The Evaluation of the Duration of Therapy for Thrombosis in Children (Kids-DOTT) multicenter, randomized trial will inform care on the optimal duration of anticoagulation in children with a transient provoking factor,8 and several phase III studies are investigating the safety and efficacy of direct oral anticoagulants in children (NCT02234843, NCT02464969, NCT01895777, NCT02234843). These and future trials will better inform therapy in pediatric VTE.
Disclosures
The authors have no financial relationships or conflicts of interest relevant to this article to disclose.
Funding
No funding was secured for this study.
