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Which medications can be split without compromising efficacy and safety?

The Journal of Family Practice. 2006 August;55(8):707-708
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Surveys of patient acceptance of tablet-splitting report varied rates (3%*#8211;74%),3,6 In 1 study,1 89% and 97% said they would split tablets to save money for themselves or their health facility, respectively.

Experts recommend assessing patients for their physical (dexterity, strength, visual acuity) and cognitive ability to split tablets, as well as whether doing so saves money.8

Recommendations from others

The American Medical Society and American Pharmacists Association oppose mandatory tablet-splitting and recommend against splitting tablets that are modified-release, combination products, unscored, film-coated, friable, or dose-critical.