Is colonoscopy indicated if only one of 3 stool samples is positive for occult blood?

Evidence-based guidelines recommend follow-up colonoscopy

Evidence-based guidelines from the United States Preventive Services Task Force, the European Commission, and the Canadian Task Force on Preventive Health Care state that FOBT should be used for colorectal cancer screening and that any positive screening test should be followed up with colonoscopy to further evaluate for neoplasm.^2-4

An evidence- and expert opinion-based guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology clarifies the issue further by emphasizing that any positive FOBT necessitates a colonoscopy and stating that repeat FOBT or other test is inappropriate as follow-up.⁵