Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Cochrane on Phytomedicines for Sickle Cell Disease

Cochrane; 2018 Feb 15; Oniyangi, Cohall, et al

Limited evidence shows that medicines derived from plants (so-called phytomedicines) may help reduce painful crises in sickle cell disease, according to a Cochrane review of 2 trials involving 282 participants. Among the findings:

  • Niprisan may help to reduce episodes of sickle cell disease crises associated with severe pain, though further trials are required to fully assess its role.
  • Ciklavit requires further study before recommendations can be made regarding its use.
  • No serious adverse symptoms or derangement of liver or kidney function was reported with either formulation.


Oniyangi O, Cohall D. Phytomedicines (medicines derived from plants) for sickle cell disease. Cochrane Database of Systematic Reviews 2018, Issue 2. Art. No.: CD004448. doi:10.1002/14651858.CD004448.pub6.

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