Clinical Edge

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Cochrane on Phytomedicines for Sickle Cell Disease

Cochrane; 2018 Feb 15; Oniyangi, Cohall, et al

Limited evidence shows that medicines derived from plants (so-called phytomedicines) may help reduce painful crises in sickle cell disease, according to a Cochrane review of 2 trials involving 282 participants. Among the findings:

  • Niprisan may help to reduce episodes of sickle cell disease crises associated with severe pain, though further trials are required to fully assess its role.
  • Ciklavit requires further study before recommendations can be made regarding its use.
  • No serious adverse symptoms or derangement of liver or kidney function was reported with either formulation.

Citation:

Oniyangi O, Cohall D. Phytomedicines (medicines derived from plants) for sickle cell disease. Cochrane Database of Systematic Reviews 2018, Issue 2. Art. No.: CD004448. doi:10.1002/14651858.CD004448.pub6.

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