Metastatic eccrine carcinoma with stomach and pericardial involvement

Skin adnexal tumors (SAT) are rare tumors that make up about 1%-2% of all cutaneous malignancies. They represent a various group of benign and malignant tumors that arise from skin adnexal epithelial structures: hair follicle, pilosebaceous unit, and apocrine or eccrine sweat glands. Although this derivation provides a practical basis for classification, some tumors may exhibit a mixed or more than one line of differentiation, rendering precise classification of those neoplasms difficult, and such cases should be categorized according to prevailing phenotype. In this report, we present a patient with metastatic eccrine carcinoma. Clinical experience for metastatic disease treatment is derived from a few reports, and there are no universal treatment guidelines. Given the few reported cases and the absence of randomized clinical trials for these patients, it is important to collect clinical experiences.

Case presentation and summary

A 56-year-old African man presented with a 5-week history of multiple nontender subcutaneous skin nodules all over his body except for his palms and soles, and associated with generalized itching. He had a mass in the sole of his right foot 35 years previously in another country. The mass had recurred 15 years later and was excised again. The exact etiology of the mass was unknown to the patient. He had no other medical problems. He was on no medications and did not smoke, drink, or use recreational drugs.

His vital signs on admission were normal. Examination was significant for innumerable superficial skin nodules in the scalp, back, torso, and abdomen. The largest was in the neck and measured 4 x 2 cm. A firm right inguinal mass of 7 x 4 cm was palpable. An abdominal exam revealed large ascites but no organomegaly.

The results of laboratory tests were significant for hyponatremia 126 mEq/L (normal, 135-145), hypercalcemia of 12.2 mg/dL (8.5-10.5), with normal phosphorous of 2.5 mg/dL (2.5-4.5), parathyroid of 11.5 pg/ml (6-65), and low vitamin D level of <7 ng/ml (30-100). Other test results were: carcinoembryonic antigen (CEA), 4.36 ng/ml (0.00-2.99); alpha fetoprotein, 2.39 IU/ml (0.00-9.0); calcium 11.6 mg/dL (8.5-10.2); lactate dehydrogenase, 325 U/L (85-210); aspartate aminotransferase, 59 U/L (0-40); alanine aminotransferase 43 U/L (5-35); alkaline phosphatase, 65 u/L (50-120); albumin, 2.7 g/dL (3.8-5.2); white blood cell count, 14.1 k/uL (4.4-10.6); hemoglobin, 12.6 g/dL; and platelets, 339 k/uL (161-369).

A chest and abdomen computed-tomography scan on presentation showed presence of innumerable subcutaneous and intramuscular nodules throughout the chest, abdomen, and pelvis (Figure 1).

Extensive peritoneal carcinomatosis in addition to moderate ascites and perivascular lymphadenopathy were evident in the abdomen cuts. Remarkably, multiple lytic, osseous metastases were seen with subacute pathologic fracture of right fourth rib in addition to mediastinal lymphadenopathy with small pericardial effusion in the chest cuts. The right thigh mass was described as a large lobulated solid and cystic mass. Ascitic fluid analysis was negative for malignant cells. Biopsy of one the skin nodules in the upper back showed carcinoma involving the skin with focal tubular differentiation (Figure 2).

Immunohistochemical stains were positive for p63, epithelial membrane antigen, high molecular weight keratin, and p40. The lesional cells were negative for CEA, bcl-2, Ber-Ep4, CK7, and CK20. The profile was compatible with a skin adnexal carcinoma of sweat gland origin. The groin lymph node showed eccrine acrospiroma.

The patient underwent an upper endoscopy to assess for recurrent vomiting and it revealed diffuse areas of large erythematous ulcerated nodules noted in the cardia, fundus, and body of the stomach (Figure 3). A biopsy of the gastric nodules revealed gastric mucosa with metastatic carcinoma.

After a thorough review of the literature, he was started on palliative chemotherapy 13 days after initial presentation with docetaxel 75 mg/m², carboplatin AUC 5 (470 mg), and 5-FU (5-fluorouracil, 750 mg/m²) over 24 hours on days 1 through 5. However, on day 2 of the chemotherapy, he became hypotensive and was found to have cardiac tamponade. He underwent an emergent pericardial window procedure. Analysis of the pericardial fluid was consistent with metastatic carcinoma (Figure 4). Chemotherapy was discontinued while he remained hypotensive requiring multiple vasopressors. His clinical condition did not improve and he passed away 27 days from initial presentation.

Discussion

Sweat gland carcinomas are very rare malignant tumors of the adnexal epithelial structures of the skin, sebaceous, hair follicle, apocrine or eccrine glands that were first described by Cornil in 1865.¹ They occur primarily in adult patients, with a peak incidence in fifth and sixth decades of life.^2,3 The etiology is unknown, but some cases have been reported to be a consequence of radiation therapy.⁴ They are almost always an incidental histologic diagnosis.^2,5 The tumors usually appear as single nodule, and multinodularity usually associated with both local and metastatic disease.⁶ There are no characteristic findings to suggest that a particular nodule may represent sweat gland carcinoma, and even if sweat gland tumor is suspected, benign counterparts are more common.