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Methyl Chloride Contamination Found in Generic Clopidogrel

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Generic Clopidogrel Poses Questions of Efficacy and Safety

FROM THE ANNUAL SCIENTIFIC SESSIONS OF THE AMERICAN HEART ASSOCIATION

The findings from this new study bring to light another issue, safety. Methyl chloride is a mutagen, possible carcinogen, and liver toxin. “When this drug is taken long-term, what will it mean for a patient’s safety,” Dr. Gurbel queried.

Dr. Thethi and his associates at Loyola said they had no disclosures. Their collaborators from Sanofi-Aventis were all employees of the company that markets clopidogrel (Plavix).

Dr. Gurbel has been a consultant to, and received honoraria and research grants from AstraZeneca, Bayer, Daiichi Sankyo, Lilly, Portola, Pozen, Sanofi-Aventis, and Schering Plough.