- The ONTARGET and TRANSCEND studies (N Engl J Med. 2008 Apr 10;358:1547-58), which together included diet and outcomes data for 31,546 patients with vascular disease. Diet analysis and scoring showed that enrolled people in the quintile with the highest score had a statistically significant 24% relative reduction in mortality, compared with the quintile with the worst score after adjusting for measured confounders.
- The INTERHEART study (Lancet. 2004 Sep 11;364:937-52), which had data for 27,098 people and showed that the primary outcome of incident MI was a statistically significant 22% lower after adjustment in the quintile with the best diet score, compared with the quintile with the worst score.
- The INTERSTROKE study (Lancet. 2016 Aug 20;388:761-75), with data for 20,834 people, showed that the rate of stroke was a statistically significant 25% lower after adjustment in the quintile with the highest diet score, compared with those with the lowest score.
Dr. Mente had no financial disclosures.