ADVANCE Yields More Data on Heart Risk in Diabetes

External validation will be needed to demonstrate the tool's potential for widespread clinical use, Dr. Kengne said.

Dr. Chalmers also discussed those findings in his presentation. “We have a plan in which an individual clinician can plug in the data and get a risk prediction score. This is potentially very useful. The next step is to validate the data in populations other than ADVANCE. We have plans to do that in two or three populations in different parts of the world.”

The ADVANCE investigators are now embarking on the ADVANCE-ON trial, in which the study participants will be observed for 5 years post study in their usual care settings. Primary outcomes will be death from any cause and major macrovascular events.

Dr. Chalmers is on the advisory board for Servier. Dr. Kengne stated that he had no conflicts of interest.