Clinical Edge Journal Scan

Diagnostic tests may miss invasive aspergillosis in children


Key clinical point : The small number of invasive aspergillosis cases may contribute to the low specificity of several tests in children after stem cell transplants and should be interpreted with caution.

Major finding: The sensitivity and specificity for probable invasive aspergillosis and potential invasive fungal disease was 80% and 55% for (1→3)-β-D-glucan (BDG); 40% and 100% for galactomannan; and 60% (and 95% (95% CI: 75–100%) for Aspergillus-specific real-time PCR.

Study details : The data come from 404 blood samples taken from 26 pediatric patients who underwent allogeneic hematopoietic stem cell transplantation between April 2016 and March 2018 at a single center.

Disclosures: The study received no outside funding. The researchers had no financial conflicts to disclose.

Source: Springer J et al. J Fungi (Basel). 2021 Mar 22. doi: 10.3390/jof7030238.

Recommended Reading

Multiple sclerosis patients may develop fungal infections on disease-modifying drugs
MDedge Infectious Disease
Echinocandins fail against wounds caused by Candida
MDedge Infectious Disease
Posaconazole posts strong results against invasive fungal infections in cancer patients
MDedge Infectious Disease
Coinfections raise mortality rates in COVID-19 patients
MDedge Infectious Disease