Mechanism of cGVHD response to ECP still unclear

These findings run contrary to the researchers’ hypothesis that response to ECP would be associated with an increase in the percentage of Tregs.

The researchers did note that the number of Tregs varied between patients, and the team raised the possibility that the mechanism of Tregs in ECP is not visible by measuring cell abundance.

However, the researchers also said future studies should explore additional mechanisms of action for ECP and look particularly at other T-cell populations, dendritic cells, inhibitory cytokines, and proinflammatory cytokines.