Bleeding Disorders
Conference Coverage
GO-8: Early promise for novel FVIII variant in hemophilia A
SAN DIEGO – The data are encouraging in the first four patients treated with the single infusion.
News
FDA aims to boost safety of platelets for transfusion
The agency is seeking input on ways to decrease the risk of bacterial contamination in platelets stored for 5 and 7 days after collection.
From the Journals
In-hospital blood saving strategy appears safe with anemia
Tolerating moderate in-hospital anemia did not negatively impact readmissions or mortality over 6 months.
News
FDA approves Nplate for pediatric ITP
Approval is for pediatric patients who’ve had ITP for at least 6 months but had no good response to corticosteroids, immunoglobulins, or...
News
Romiplostim now approved for children with ITP
The thrombopoietin receptor agonist romiplostim (NPlate®) is now approved by the U.S.
Conference Coverage
Rapid test could solve Africa’s sickle cell screening problem
SAN DIEGO – The simple blood test costs about $2 and has an accuracy of 99%.
Conference Coverage
Factor IX expression stable at up to 8 years with gene therapy
SAN DIEGO – In severe hemophilia B, factor IX expression remains stable up to 8.6 years after scAAV2/8-LP1-hFIX–comediated gene therapy.
Conference Coverage
DOAC pause yields favorable outcomes for AF patients
SAN DIEGO – Results from the PAUSE study could set the standard for timing of perioperative DOAC interruption.
Conference Coverage
Lower-dose rituximab may be enough in acquired TTP
SAN DIEGO – A lower dose of rituximab appears effective, but it still carries side effects.
Conference Coverage
MEDALIST: Erythroid maturation agent reduced transfusion burden in MDS
SAN DIEGO – Luspatercept also showed promise in a phase 3 trial including adults with beta-thalassemia.
From the Journals
Heavy menstrual bleeding in teens often linked to bleeding disorders
Over one-third of adolescents presenting with heavy menstrual bleeding were diagnosed with a bleeding disorder after screening.