Complications and outcomes of different management pathways of CRC and synchronous liver metastases

November 15, 2021|Hematology and Oncology

Clinical Edge Journal Scan: CRC December 2021 (1 of 11)

Key clinical point: Management of colorectal cancer (CRC) and synchronous liver metastases with staged liver-first or bowel-first routes or synchronous combined liver and bowel surgery, all with contemporary systemic chemotherapy, led to similar perioperative complications and oncological outcomes.

Major finding: Postoperative complications (P = .66), total critical care occupancy (P = .92) and mean total inpatient stay (P = .91) were similar between synchronous and staged management pathways. Overall, 35% of patients were disease-free at 12 months, with no difference between groups (P = .448).

Study details: Findings are from CoSMIC, a prospective inception cohort study including 125 patients with CRC and synchronous liver metastases.

Disclosures: AKC Chan was supported by a grant from the Dickinson Trust.

Source: Chan AKC et al. Ann Surg Oncol. 2021 Oct 30. doi: 10.1245/s10434-021-11017-7.