Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Does Elevated Lp(a) & FH Increase CAD Risk?

Clin Cardiol; ePub 2018 Feb 26; Ellis, Pang, et al

In patients admitted to the coronary care unit (CCU), the combination of elevated lipoprotein(a) (Lp[a]) and familial hypercholesterolemia (FH) is associated with increased coronary artery disease (CAD) risk, a recent study found. Plasma Lp(a) concentrations were measured in consecutive patients admitted to the CCU with an acute coronary syndrome (ACS) or prior history of CAD for 6.5 months. Premature CAD was diagnosed in those aged <60 years, with the relationship between this and elevated Lp(a) and FH determined by logistic regression. Among the details:

  • 316 patients were screened; 163 (51.6%) had premature CAD.
  • Elevated Lp(a) and FH were identified in 27.0% and 11.6% of patients, respectively.
  • Both disorders were identified in 4.4% of individuals.
  • Elevated Lp(a) and FH phenotype were more common with premature vs nonpremature CAD.


Ellis KL, Pang J, Chieng D, et al. Elevated lipoprotein(a) and familial hypercholesterolemia in the coronary care unit: Between Scylla and Charybdis. [Published online ahead of print February 26, 2018]. Clin Cardiol. doi:10.1002/clc.22880.

This Week's Must Reads

AHA Statement on Promotion of Physical Activity, Circulation; ePub 2018 Apr 4; Lobelo, et al

ADHF Readmissions in Patients with HFrEF, Am J Cardiol; ePub 2018 Mar 28; Caughey, et al

Ischemic Events in Patients with PAD After an ACS, Am Heart J; ePub 2018 Mar 28; Inohara, et al

Efficacy of NOACs in Patients with AF and VHD, J Am Heart Assoc; ePub 2018 Apr 5; Briasoulis, et al

Screening and Statin Treatment in Patients with FH, Circulation; ePub 2018 Mar 26; Bucholz, et al

Must Reads in Hypercholesterolemia

Screening and Statin Treatment in Patients with FH, Circulation; ePub 2018 Mar 26; Bucholz, et al

Lipid Guideline Adoption & Observed Implementation, Am Heart J; ePub 2018 Mar 26; Lowenstern, et al

LDL-C Lowering in Patients at Intermediate CV Risk, Clin Cardiol; ePub 2018 Mar 25; Cesena, et al

FH and High LDL-C in Risk of Ischemic Stroke, Circulation; ePub 2018 Mar 28; Beheshti, et al

Can Plant-Based Diets Treat Hypercholesterolemia?, Clin Cardiol; ePub 2018 Mar 25; Najjar, et al