Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Does Elevated Lp(a) & FH Increase CAD Risk?

Clin Cardiol; ePub 2018 Feb 26; Ellis, Pang, et al

In patients admitted to the coronary care unit (CCU), the combination of elevated lipoprotein(a) (Lp[a]) and familial hypercholesterolemia (FH) is associated with increased coronary artery disease (CAD) risk, a recent study found. Plasma Lp(a) concentrations were measured in consecutive patients admitted to the CCU with an acute coronary syndrome (ACS) or prior history of CAD for 6.5 months. Premature CAD was diagnosed in those aged <60 years, with the relationship between this and elevated Lp(a) and FH determined by logistic regression. Among the details:

  • 316 patients were screened; 163 (51.6%) had premature CAD.
  • Elevated Lp(a) and FH were identified in 27.0% and 11.6% of patients, respectively.
  • Both disorders were identified in 4.4% of individuals.
  • Elevated Lp(a) and FH phenotype were more common with premature vs nonpremature CAD.


Ellis KL, Pang J, Chieng D, et al. Elevated lipoprotein(a) and familial hypercholesterolemia in the coronary care unit: Between Scylla and Charybdis. [Published online ahead of print February 26, 2018]. Clin Cardiol. doi:10.1002/clc.22880.

This Week's Must Reads

CAD Severity as a Function of Patient Sex, Am Heart J; ePub 2018 Oct 2; Pagidipati, et al

PCI Trends Among Elderly Patients with ACS, Am J Cardiol; ePub 2018 Sep 27; Elbadawi, et al

Obtaining a Reliable Estimate of Home Blood Pressure, J Am Heart Assoc; ePub 2018 Oct 5; Bello, et al

Liraglutide & CV Events in Patients with T2D & CKD, Circulation; ePub 2018 Oct 3; Mann, et al

Detection & Management of Resistant Hypertension, Hypertension; ePub 2018 Sep 13; Carey, et al

Must Reads in Hypercholesterolemia

Racial Differences in Statin Use, JAMA Cardiol; ePub 2018 Jun 13; Nanna, et al

LLT Use in Patients with Elevated LDL-C, Circ Cardiovasc Qual Outcomes; ePub 2018 May 10; Virani, et al

Evolocumab in Differing Patient Populations , J Pharmacokinet Pharmacodyn; ePub 2018 May 7; Kuchimanchi, et al

LDL-C Targets in Elderly Statin Users After ACS, J Am Heart Assoc; ePub 2018 May 12; Alter, et al

Patient Perspectives on Statin Therapy, Clin Cardiol; ePub 2018 May 10; Brinton