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Sex-related differences in antidepressant response: When to adjust treatment

Current Psychiatry. 2010 May;09(05):25-30
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How pharmacodynamic, pharmacokinetic, and hormonal factors impact prescribing

Related resources

  • Rubinow DR, Schmidt PJ, Roca CA. Estrogen-serotonin interactions: implications for affective regulation. Biol Psychiatry. 1998;44(9):839-850.
  • Cohen LS, Nonacs RM, eds. Mood and anxiety disorders during pregnancy and postpartum. Arlington, VA: American Psychiatric Publishing, Inc.; 2005.
  • Kornstein SG, Schatzberg AF, Thase ME, et al. Gender differences in treatment response to sertraline versus imipramine in chronic depression. Am J Psychiatry. 2000;157(9):1445-1452.

Drug brand names

  • Bupropion • Wellbutrin
  • Citalopram • Celexa
  • Clomipramine • Anafranil
  • Duloxetine • Cymbalta
  • Escitalopram • Lexapro
  • Estradiol • Estrace, Climara, others
  • Fluoxetine • Prozac
  • Fluvoxamine • Luvox
  • Imipramine • Tofranil
  • Mirtazapine • Remeron
  • Nefazodone • Serzone
  • Nortriptyline • Pamelor
  • Sertraline • Zoloft
  • Venlafaxine • Effexor

Disclosures

Dr. Marsh receives grant/research support from the University of Massachusetts.

Dr. Deligiannidis receives grant/research support from the Worcester Foundation for Biomedical Research and Forest Research Institute.

Acknowledgement

Dr. Deligiannidis’ contribution to this article was supported by the University of Massachusetts Medical School Department of Psychiatry and the University of Massachusetts Medical School Center for Psychopharmacologic Research and Treatment.