Topics include: BRCA1 mutations and endometrial cancer risk • Treatment for scalp psoriasis • Azithromycin-resistant gonorrhea • Statins and ovarian cancer survival • Chronic opioid use and common surgeries
VITALSKey clinical point: Clinicians may wish to discuss the option of hysterectomy at the time of salpingo-oophorectomy in women with deleterious BRCA1 mutations. Major finding: Among women with BRCA1 but not BRCA2 mutations there was increased risk for serous/serous-like endometrial carcinomas. Data source: Prospective multicenter follow-up study of 1,083 women with BRCA mutations who underwent salpingo-oophorectomy without hysterectomy. Disclosures:The study was supported by grants from the Department of Defense, National Institutes of Health, and public and private foundations. Coauthor Robert Soslow, MD, disclosed consulting for EMD Serono. No others reported conflicts of interest. The editorialists reported no conflicts of interest related to the study.
2. Cochrane Review: Topical Steroid—Vitamin D Combo Best for Scalp Psoriasis
VITALSKey clinical point: The combination of a topical steroid and topical vitamin D is marginally better but with a similar safety profile to steroids alone as a treatment for psoriasis on the scalp. Major finding: The combination of a topical steroid and vitamin D showed a small but statistically significant advantage over steroids alone, and a greater advantage over vitamin D alone. Data source: A systematic review of 59 randomized controlled studies in 11,561 patients . Disclosures:The study was supported by the Universidade Federal de SÃ£o Paulo, Brazil; the Universidade Federal do Rio Grande do Norte, Brazil; and the National Institute for Health Research, United Kingdom. Six authors and one clinical referee declared speakers' fees, research grants, and funding from the pharmaceutical industry. One author had no conflicts of interest to disclose.
3. Study Finds Emergence of Azithromycin-resistant Gonorrhea
VITALSKey clinical point: Resistance to azithromycin is emerging among patients diagnosed with gonorrhea . Major finding: Among patients with gonorrhea, resistance to azithromycin increased from 0.6% in 2013 to 2.5% in 2014, predominantly in the Midwest. Data source: An analysis of 5,093 Neisseria gonorrhoeae isolates from 27 clinics as part of the CDC's Gonococcal Isolate Surveillance Project. Disclosures:The researchers had no financial disclosures.
VITALSKey clinical point: The risk of all-cause mortality in ovarian cancer patients on statin therapy was reduced by one-third. Major finding: Mean survival in a large cohort of women with stage III ovarian cancer was 5.8 months longer among those on statin therapy. Data source: A retrospective study of 1,510 women diagnosed with epithelial ovarian cancer during 2007-2009. Disclosures:Dr. Vogel reported having no financial conflicts regarding this study, conducted without commercial support.
5. Common Surgeries Linked to Chronic Opioid Use Among Opioid-naive Patients