MS-Like Syndromes Slow Pediatric Brain Growth, Cognition

In multiple linear regression models, age at disease onset was the main significant predictor of verbal intelligence and processing speed, accounting for 23%-37% of the total variation in the two. The addition of total brain lesion volume to these models accounted for another 4%-11% of the total variation.

The total brain T2 lesion volume was the main significant predictor of the global cognitive composite score as well as scores on the sustained visual attention test, after controlling for covariates.

Dr. Till said she had no conflict of interest to disclose. Two of her research collaborators disclosed receiving compensation for speaking for manufacturers of drugs for MS.